A multi-institutional team has developed three cost-effective kits that improve the diagnosis of drug-resistant TB.The three kits are TB Detect, TB Concentration & Transport, and TB DNA Extraction. The TB Detect kit is for diagnosis using LED fluorescence microscopy.
The TB Concentration & Transport, and the TB DNA Extraction kits together are for detection of drug-resistance. The team includes researchers from the Department of Biotechnology at AIIMS and the Advanced Microdevices Pvt Ltd, Ambala.
Benefits: The TB Detect kit helps increase the positivity of LED fluorescence microscopy by about 5%. The TB DNA Extraction kit allows the detection of drug-resistant TB bacteria with a high level of sensitivity. The kits are not expensive. The TB Detect kit currently costs Rs.100 per sample, Rs.100 for the TB transport kit and Rs.85 for the DNA extraction kit.
The TB concentration & transport kit now makes it easy and simple to transport samples, transport it in sealed covers at ambient temperature making containment at low temperature redundant.This is because the bacteria are killed using a disinfectant.The developed kits are to be evaluated for operational feasibility and performance in field settings under Revised National Tuberculosis Control Program (RNTCP).
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